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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
Published on: November 30, 2016
Colorectal hepatic metastases: quantitative measurements using single-shot echo-planar diffusion-weighted MR imaging
D M Koh1, E Scurr, D J Collins
1Cancer Research UK Magnetic Resonance Clinical Research Group, Institute of Cancer Research, Sutton, UK. dowmukoh@icr.ac.uk
European Radiology
|May 13, 2006
Summary
This study measured diffusion coefficients and perfusion fractions in liver metastases from colorectal cancer. Colorectal hepatic metastases show higher diffusion but lower perfusion compared to normal liver tissue.
Area of Science:
- Radiology and Imaging Science
- Oncology
- Gastroenterology
Background:
- Hepatic metastases from colorectal carcinoma are common.
- Diffusion-weighted imaging (DWI) offers quantitative insights into tissue microstructures.
- Distinguishing metastases from normal liver parenchyma is crucial for diagnosis and management.
Purpose of the Study:
- To quantitatively measure apparent diffusion coefficient (ADC1), flow-insensitive apparent diffusion coefficient (ADC2), and perfusion fraction (F) in colorectal hepatic metastases using DWI.
- To compare these quantitative DWI parameters between hepatic metastases and normal liver parenchyma.
Main Methods:
- Prospective evaluation of 40 patients with 66 colorectal hepatic metastases using DWI with three b values (0, 150, 500 s/mm2).
- Calculation of quantitative maps for ADC1 (b=0, 150, 500), ADC2 (b=150, 500), and fractional variation (F) reflecting perfusion fraction.
- Statistical comparison of ADC1, ADC2, and F values between metastases and liver parenchyma using paired t-test and Mann-Whitney test.
Main Results:
- Mean ADC1 and ADC2 values were significantly higher in colorectal hepatic metastases compared to liver parenchyma (P < 0.0001).
- The perfusion fraction (F) was significantly lower in metastases compared to liver parenchyma (P = 0.03).
- Both ADC1 and ADC2 showed significant increases, while F showed a significant decrease in metastases versus liver.
Conclusions:
- Colorectal hepatic metastases exhibit distinct quantitative DWI characteristics compared to normal liver parenchyma.
- Higher ADC1 and ADC2 values in metastases suggest altered water diffusion.
- Lower perfusion fraction (F) in metastases indicates reduced microvascular blood flow compared to the liver.
