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A novel furanocoumarin from Feroniella lucida exerts protective effect against lipid peroxidation
Preecha Phuwapraisirisan1, Serm Surapinit, Santi Tip-Pyang
1Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. preecha.p@chula.ac.th
Phytotherapy Research : PTR
|May 13, 2006
Abstract:
The protective effect of Feroniella lucida against lipid peroxidation was investigated. Bioassay-guided separation using rat brain as a model led to the isolation of a new antioxidant furanocoumarin named feroniellamin (6) along with five known coumarins. The structure of 6 was characterized by interpretation of spectroscopic data. Feroniellamin inhibited lipid peroxidation with an IC(50) value of 52 microM.