[Molecular collagen content and polymorphism in the breast with benign dysplasia]

A significant increase in collagen content in breast benign dysplasia has been noted in comparison with normal breasts. Type I and type III collagens were isolated from the normal breast. These types constitute 70% and 25% of the total collagen contents in breast, respectively. It was found, that the major part of tumor collagen is present in the form of type I and type III collagens stable complex. This complex does not dissociate under conditions used for collagen isolation. Normal female breast does not contain such a complex.