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Smoking, pulmonary function, and mortality.

J D Curb1, E B Marcus, D M Reed

  • 1Honolulu Heart Program, Kuakini Medical Center, HI 96817.

Annals of Epidemiology
|October 1, 1990
PubMed
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Pulmonary function, measured as forced expiratory volume in 1 second (FEV1), is linked to mortality risk, but this association is primarily driven by smoking history in Japanese-American men.

Area of Science:

  • Epidemiology
  • Pulmonary Medicine
  • Biostatistics

Background:

  • Pulmonary function is a key indicator of respiratory health.
  • Its association with long-term mortality requires further investigation, particularly considering confounding factors like smoking.
  • Understanding these relationships can inform public health strategies and clinical risk assessment.

Purpose of the Study:

  • To investigate the association between pulmonary function (percent predicted forced expiratory volume in 1 second [FEV1]) and total and cause-specific mortality.
  • To examine the influence of smoking history on this association.
  • To explore potential interactions between smoking status and pulmonary function in predicting mortality.

Main Methods:

  • Prospective cohort study of 5924 Japanese-American men.

Related Experiment Videos

  • Longitudinal follow-up for 15 to 18 years.
  • Multivariate statistical analysis adjusting for potential confounders, including smoking status and interaction terms.

    • Main Results:

    • In never-smokers, pulmonary function was not significantly predictive of total mortality after multivariate adjustment.
    • In past and current smokers, highly significant associations (P < 0.0001) were found between pulmonary function and mortality.
    • A statistically significant interaction (P < 0.003) between smoking and pulmonary function was observed, indicating smoking history modifies the mortality risk associated with lung function.

    Conclusions:

    • Pulmonary function is associated with subsequent mortality, but this relationship is significantly moderated by smoking history.
    • The strong link between pulmonary function and mortality in smokers overshadows the association in non-smokers.
    • Complex interactions between biologic variables, such as smoking and pulmonary function, must be considered in multivariate analyses.