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Induction of microsomal drug metabolizing enzymes by phenobarbitone in the rats exposed to increased environmental
J Pachecka1, K Kobylińska, H Zasłona
1Department of Drug Metabolism, School of Medicine, Warsaw, Poland.
Acta Poloniae Pharmaceutica
|January 1, 1991
Abstract:
Exposure of rats for 3 consecutive days (6 h a day) to 28 degrees C or 35 degrees C does not lead to changes in the induction of hepatic microsomal cytochrome P-450 associated monooxygenases by phenobarbitone as compared with control animals exposed to 21 degrees C. These results suggest that environmental temperature does not change the capacity of phenobarbitone to induce drug metabolizing enzymes in rat liver.