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Multiple drug intolerance: allergological and psychological findings
G Patriarca1, D Schiavino, E Nucera
1Department of Allergology, Catholic University, Rome, Italy.
Summary
Patients with multiple drug intolerance, often self-diagnosed as allergic, may have underlying psychosomatic factors. Psychodiagnostic testing reveals suppressed emotions and depressive feelings, suggesting a complex interplay of psychological and physiological elements in drug intolerance.
Area of Science:
- Psychiatry
- Pharmacology
- Immunology
Background:
- Patients self-diagnosing as
Purpose of the Study:
- To investigate the potential psychosomatic component in patients with multiple drug intolerance.
- To evaluate pseudoallergic reactions in a cohort of drug-intolerant individuals.
Main Methods:
- Studied 20 female patients with intolerance to at least three chemically dissimilar drugs.
- Conducted allergological testing (negative in all cases) and Rorschach psychodiagnostic tests.
- Compared psychodiagnostic findings with 20 healthy control subjects.
Main Results:
- Psychodiagnostic tests revealed a negative psychological constitution in the patient group.
- Patients exhibited suppressed emotions, reduced emotional expression, and increased depressive feelings.
- Identified potential early-life emotional developmental factors contributing to suppressed affection expression.
Conclusions:
- Multiple drug intolerance has a complex etiology, including psychosomatic factors.
- Psychosomatic components, characterized by emotional suppression and depressive feelings, are significant in drug intolerance.
- Psychodiagnostic testing is crucial for a comprehensive diagnosis of multiple drug intolerance.