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Immunomodulatory activity of plasmatic substances
A M Lauricella1, H L Goldman, E J Massouh
1Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Journal of Investigational Allergology & Clinical Immunology
|October 1, 1991
Summary
Chronic renal failure (CRF) plasma inhibits lymphocyte proliferation, but fractions show differing effects. CRF plasma fractions may have qualitative differences, potentially explaining uremic immunodeficiency.
Area of Science:
- Immunology
- Nephrology
- Biochemistry
Background:
- Uremic immunodeficiency is a recognized complication in patients with chronic renal failure (CRF).
- Circulating substances in CRF patients' plasma are hypothesized to contribute to immune dysfunction.
Purpose of the Study:
- To investigate the activity of plasma and plasma fractions from CRF patients on lymphocyte proliferation in vitro.
- To identify potential circulating factors responsible for uremic immunodeficiency.
Main Methods:
- Plasma and molecular weight (MW) fractions (A and B) from 12 CRF patients and 12 normal subjects were analyzed.
- In vitro assays were performed on PHA-stimulated normal lymphocyte cultures.
- Dose-response curves were evaluated for inhibitory and stimulatory effects.
Main Results:
- CRF plasma significantly inhibited lymphoproliferation compared to normal plasma (p < 0.001).
- CRF plasma fractions showed variable effects, with many exhibiting stimulatory activity, unlike normal fractions which were primarily inhibitory.
- Qualitative differences were observed between CRF and normal plasma fractions, suggesting altered immunomodulatory substances.
Conclusions:
- Normal plasma fractions contain immunomodulatory substances with both inhibitory and stimulatory activities.
- Disruptions in these immunomodulatory systems within CRF plasma may underlie the observed immunodeficiency in these patients.