[Colposcopic, cytologic and histologic changes in the uterine cervix caused by human papilloma viruses]

This study is an evaluation of 485 histological findings of directed biopsies, which were performed due to the cytological state of dysplasia (IIIA and IIIB) or an abnormal colposcopy finding. The analysis of cervical smears showed 18.4% of the patients to have koilocytosis, whereas 6.8% of them had colposcopically recognized cervical condyloma. The samples obtained by biopsy underwent histological examination, which confirmed koilocytotic changes in 8.5% of cases, i. e. in significantly lower percentage than indicated by cytology (t = 4.500; p < 0.001). Colposcopy findings of condyloma, on the other hand, were confirmed much more often (60.6% compared to 31.5%; t = 3.163, p < 0.001, i. e. the difference is statistically significant). Pathohistological examination verified 68.3% of cytologically recognized cases of koilocytosis, compared to 48.8% of cytologically recognized cases of koilocytosis, compared to 48.8% of those discovered by colposcopy--the difference is not significant (t = 1.822; p > 0.05). However, the joint implementation of cytology and colposcopy revealed 85.4% of koilocytoses. Compared to the results of colposcopy as the single method, the difference is statistically significant (t = 3.812; p < 0.001), but compared to cytology it is not (t = 1.879; p > 0.05). Koilocytosis is significantly more frequent in women under 35 years of age (82.9%; t = 4.218, p < 0.001) and the patients suffering from it are also much more likely to have dysplasia or CIS than those with no HPV infection (58.5% compared to 42.4%; t = 2.012, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)