Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroblastoma screening data. An epidemiologic analysis.

S N Goodman1

  • 1Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Md.

American Journal of Diseases of Children (1960)
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colorectal cancer in ulcerative colitis: survival in patients with and without colorectal cancer symptoms.

Inflammatory bowel diseases·2013
Same author

WITHDRAWN: Anticoagulants or antiplatelet therapy for non-rheumatic atrial fibrillation and flutter.

The Cochrane database of systematic reviews·2007
Same author

Left insular stroke is associated with adverse cardiac outcome.

Neurology·2006
Same author

Pancreatic cancer after remote peptic ulcer surgery.

Journal of clinical pathology·2002
Same author

Management of acne.

Evidence report/technology assessment (Summary)·2002
Same author

Anticoagulants or antiplatelet therapy for non-rheumatic atrial fibrillation and flutter.

The Cochrane database of systematic reviews·2001
Same journal

Nonsteroidal anti-inflammatory drugs and gastrointestinal injury in children.

American journal of diseases of children (1960)·1993
Same journal

Picture of the month. Cutaneous leishmaniasis.

American journal of diseases of children (1960)·1993
Same journal

Pathological case of the month. Wells' syndrome.

American journal of diseases of children (1960)·1993
Same journal

Radiological case of the month. Proteus syndrome: benign angiolipomatous tumor with intraspinal extension.

American journal of diseases of children (1960)·1993
Same journal

Applicability of the Greulich and Pyle skeletal age standards to black and white children of today.

American journal of diseases of children (1960)·1993
Same journal

Maltreatment of children born to cocaine-dependent mothers.

American journal of diseases of children (1960)·1993
See all related articles

Mass screening for neuroblastoma (a common childhood cancer) in infants shows limited evidence of benefit. The Japanese screening program data may overestimate advantages due to overdiagnosis and potentially miss aggressive tumors.

Area of Science:

  • Pediatric Oncology
  • Epidemiology
  • Public Health Screening

Background:

  • Neuroblastoma is a frequent pediatric malignancy, particularly in children under five.
  • Prognosis for advanced neuroblastoma has seen minimal improvement over the last 30 years.
  • Early detection via mass infant screening using urine tests for neuroblastoma metabolites has been proposed to reduce mortality.

Purpose of the Study:

  • To critically evaluate the efficacy of mass neuroblastoma screening programs using established epidemiologic criteria.
  • To assess the validity of reported benefits from Japanese mass screening initiatives.
  • To examine the potential impact of overdiagnosis and the detection of indolent tumors.

Main Methods:

  • Application of standard epidemiologic criteria for screening evaluations.

Related Experiment Videos

  • Analysis of published reports from Japanese mass screening programs for neuroblastoma.
  • Review of recent biological understanding of neuroblastoma and its prognostic indicators.

    • Main Results:

    • Data presented in Japanese reports were insufficient to definitively confirm the value of neuroblastoma screening.
    • Claimed benefits may be inflated due to overdiagnosis, detecting tumors that might not have caused harm.
    • Screening at 6 months may fail to identify neuroblastomas with poor prognoses, and early detection's impact on outcomes remains uncertain.

    Conclusions:

    • The current evidence does not conclusively establish the benefit of mass neuroblastoma screening.
    • Screening program evaluations require robust, age-specific, population-based incidence and mortality data.
    • These studies highlight the critical need for caution when interpreting screening results without comprehensive epidemiological data.