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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways

Gavin W Porter1, Fadlo R Khuri, Haian Fu

  • 1Department of Pharmacology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA. gporter@emory.edu

Seminars in Cancer Biology
|May 16, 2006
PubMed

Insights

The 14-3-3 protein regulates apoptosis by interacting with various cellular proteins. Targeting 14-3-3 interactions offers a potential cancer therapy by inhibiting overactive survival pathways.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The 14-3-3 protein family is a conserved group of serine/threonine binding proteins.
  • 14-3-3 proteins interact with a wide range of client proteins, influencing numerous cellular processes.
  • These proteins play a critical role in regulating apoptosis, the process of programmed cell death.

Purpose of the Study:

  • To elucidate the multifaceted role of 14-3-3 proteins in apoptosis regulation.
  • To explore the therapeutic potential of targeting 14-3-3 protein interactions in cancer treatment.

Main Methods:

  • The study reviews existing literature on 14-3-3 protein interactions and their involvement in apoptosis.
  • Analysis of signaling pathways and molecular mechanisms underlying 14-3-3 mediated apoptosis suppression and induction.

Main Results:

  • 14-3-3 proteins inhibit apoptosis by sequestering pro-apoptotic client proteins and coordinating with survival kinases.
  • Cellular stress can induce apoptosis by inhibiting 14-3-3 protein function.
  • Global inhibition of 14-3-3/client protein interactions triggers apoptosis.

Conclusions:

  • 14-3-3 proteins are key regulators of apoptosis, acting as crucial checkpoints in cell survival and death.
  • Dysregulation of 14-3-3 proteins is linked to poor prognosis in cancer patients.
  • Targeting 14-3-3 protein interactions presents a promising therapeutic strategy for cancers characterized by aberrant survival signaling.

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