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Related Experiment Videos

Rubella vaccination in pregnancy.

P A Tookey1, G Jones, B H Miller

  • 1Epidemiology and Biostatistics Unit, Institute of Child Health, London.

CDR (London, England : Review)
|July 19, 1991
PubMed
Summary

Inadvertent rubella vaccination during pregnancy poses a low risk of harm to the fetus. These findings support current medical advice against routine pregnancy termination after rubella vaccination.

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Rubella seroprevalence in pregnant women in North Thames: estimates based on newborn screening samples.

Journal of medical screening·2009

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Vaccinology

Background:

  • Rubella vaccination is crucial for preventing congenital rubella syndrome.
  • Concerns exist regarding the safety of rubella vaccination during pregnancy.

Purpose of the Study:

  • To assess the risk of rubella-associated damage following inadvertent rubella vaccination in pregnancy.
  • To evaluate outcomes of pregnancies exposed to rubella vaccination.

Main Methods:

  • Retrospective analysis of 92 pregnancies reported to the Rubella Vaccination in Pregnancy Study (1981-1990).
  • Documented pregnancy outcomes including live births, stillbirths, and spontaneous abortions.
  • Monitored infants for evidence of congenital rubella infection and damage.

Main Results:

  • 87 live births, 3 stillbirths, and 2 spontaneous abortions were recorded.
  • One infant showed serological evidence of congenital rubella infection but had no clinical damage at 2.5 years.
  • The overall risk of rubella-associated damage appears low.

Conclusions:

  • Inadvertent rubella vaccination in pregnancy or preconception is associated with a low risk of fetal damage.
  • Routine termination of pregnancy is not recommended in cases of inadvertent rubella vaccination.

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