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Related Experiment Videos

Triclosan loaded ureteral stents decrease proteus mirabilis 296 infection in a rabbit urinary tract infection model.

Peter A Cadieux1, Ben H Chew, Bodo E Knudsen

  • 1Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada.

The Journal of Urology
|May 16, 2006
PubMed
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Triclosan-eluting ureteral stents significantly reduced Proteus mirabilis growth and survival in a rabbit urinary tract infection model. These findings suggest potential for reducing device-related infections.

Area of Science:

  • Urology
  • Infectious Diseases
  • Biomaterials

Background:

  • Ureteral stent use is limited by infection and encrustation.
  • Proteus mirabilis is a common cause of device-related urinary tract infections (UTIs) and encrustation.
  • Novel stent coatings are needed to overcome these limitations.

Purpose of the Study:

  • To evaluate the efficacy of triclosan-eluting ureteral stent segments against Proteus mirabilis in a rabbit UTI model.
  • To assess the impact of triclosan on bacterial growth, survival, and bladder inflammation.

Main Methods:

  • 48 rabbits were instilled with P. mirabilis.
  • Triclosan-eluting or control ureteral stent segments were placed intravesically.
  • Urine, stents, and bladders were analyzed for bacterial load, encrustation, and inflammation.

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Main Results:

  • Triclosan stents significantly reduced viable P. mirabilis in urine and on stent surfaces compared to controls.
  • 70% of animals with triclosan stents cleared the infection by day 7.
  • Less bladder inflammation was observed in the triclosan group, though encrustation rates were similar.

Conclusions:

  • Triclosan-eluting ureteral stents effectively inhibit P. mirabilis growth and survival.
  • These stents show promise for reducing device-related P. mirabilis UTIs.