Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Botulinum-A toxin injections into the detrusor muscle decrease nerve growth factor bladder tissue levels in patients

Antonella Giannantoni1, Savino M Di Stasi, Vincenza Nardicchi

  • 1Department of Urology, University of Perugia, Perugia, Italy. agianton@tin.it

The Journal of Urology
|May 16, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of safety and feasibility of on-clamp versus off-clamp robotic partial nephrectomy.

Urologia·2026
Same author

FGFR3 Alterations and Nectin-4 Expression as Therapeutic Biomarkers in Bladder Cancer: A Systematic Review and Single-Arm Meta-Analysis.

International journal of molecular sciences·2026
Same author

Preventing Parastomal Hernias After Radical Cystectomy with Ileal Conduit: A Systematic Review Regarding Surgical Prophylactic Techniques.

Journal of personalized medicine·2026
Same author

Molecular and functional characterization of GMP-manufactured neural stem cells and their extracellular vesicles for innovative therapeutic applications.

Stem cell research & therapy·2026
Same author

Mechanistic Fingerprints from Chloride to Iodide: Halide vs. Ammonia Release in Platinum Anticancer Complexes.

International journal of molecular sciences·2025
Same author

Incisional Negative-Pressure Wound Therapy Versus Standard Dressing for the Prevention of Surgical Site Complications Following Radical Cystectomy.

Journal of personalized medicine·2025

Botulinum toxin type A (BTX-A) injections reduced nerve growth factor (NGF) in bladder tissue for neurogenic detrusor overactivity patients. This treatment improved urodynamic parameters and decreased incontinence episodes.

Area of Science:

  • Urology
  • Neuroscience

Background:

  • Neurogenic detrusor overactivity (NDO) is a condition characterized by involuntary bladder contractions.
  • Visceral afferent nerve transmission plays a role in NDO pathophysiology, with nerve growth factor (NGF) implicated.

Purpose of the Study:

  • To investigate the effect of intravesical botulinum toxin type A (BTX-A) on visceral afferent nerve transmission in NDO patients.
  • To measure bladder tissue NGF levels before and after BTX-A treatment.
  • To correlate NGF levels with clinical and urodynamic outcomes.

Main Methods:

  • 23 NDO patients received intravesical BTX-A treatment.
  • Clinical evaluation and urodynamics (UDC threshold, maximum pressure, maximum cystometric capacity) were performed at baseline and 1, 3 months post-treatment.

Related Experiment Videos

  • Bladder biopsies were obtained for NGF level measurement using ELISA.

    • Main Results:

    • BTX-A treatment significantly decreased catheterization and incontinence episodes at 1 and 3 months.
    • Urodynamic parameters showed significant improvement: increased UDC threshold and maximum cystometric capacity, and decreased UDC maximum pressure.
    • Bladder tissue NGF levels were significantly reduced at 1 and 3 months post-treatment.

    Conclusions:

    • Intravesical BTX-A treatment leads to NGF deprivation in bladder tissue for at least 3 months.
    • Reduced acetylcholine release may decrease detrusor contractility and NGF production.
    • BTX-A might also affect other neurotransmitters modulating NGF production and release.