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Updated: Aug 8, 2026
A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis
Published on: July 12, 2019
[Microdialysis and brain injury: importance of animal study]
T Geeraerts1, A Friggeri, B Vigué
1Département d'anesthésie-réanimation chirurgicale, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, France. thgeeraerts@hotmail.com
Abstract:
Brain microdialysis allows the exploration of brain extracellular medium. This review discusses the main contribution of brain microdialysis for the knowledge of the pathophysiology of brain ischemia and trauma. We describe fundamental principle of microdialysis, limits, and validated metabolic parameters as the lactate/pyruvate ratio or glycerol. The interest to use microdialysis for testing metabolic hypothesis and potential scientific research ways will also be discussed.
