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Updated: Jun 16, 2026
09:41
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
Published on: July 3, 2014
[Intracerebral haemorrhage, what's new?]
1Département d'Anesthésie-Réanimation, CHU de La Timone-Adultes, 264, rue Saint-Pierre, 13385 Marseille, France.
Annales Francaises D'Anesthesie Et De Reanimation
|May 16, 2006
Summary
Recombinant activated factor VII shows promise in reducing mortality and disability from haemorrhagic stroke when administered early. Aggressive blood pressure management may also be beneficial, but surgery has not shown positive outcomes.
Area of Science:
- Neurology
- Neurosurgery
- Critical Care Medicine
Context:
- Haemorrhagic stroke (HS) presents significant mortality and morbidity, with limited functional recovery for survivors.
- Anticoagulation exacerbates HS, and delayed coagulation normalization worsens hematoma expansion.
- Current treatments lack efficacy, highlighting the need for novel therapeutic strategies.
Purpose:
- To evaluate the efficacy of recombinant activated factor VII (rFVIIa) in reducing hematoma growth, mortality, and disability in patients with HS.
- To assess the impact of early aggressive blood pressure and intracranial pressure management on HS outcomes.
- To review the findings of surgical interventions for HS, such as the STICH trial.
Summary:
- A phase II trial indicated that rFVIIa, administered within 4 hours of stroke onset, effectively reduced hematoma expansion, mortality, and disability.
- Early, aggressive control of blood pressure and intracranial pressure appears beneficial in managing HS.
- The STICH trial found no significant benefit from surgical intervention in patients with HS.
Impact:
- Early rFVIIa administration could represent a breakthrough in HS treatment, improving patient survival and functional independence.
- Optimized hemodynamic management strategies are crucial for mitigating secondary brain injury after HS.
- Evidence suggests that surgical interventions may not be beneficial for all HS patients, necessitating careful patient selection and treatment planning.
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