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Assessment of common idiotype PR4-Id in serial bleeds from lupus patients
C Pilcher1, W Williams, D A Isenberg
1Department of Rheumatology Research, University College & Middlesex Hospital Medical School, London.
Autoimmunity
|January 1, 1991
Abstract:
Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression was not simply related to total immunoglobulin levels and the controlling mechanisms of idiotype expression on different isotypes remain a matter of conjecture.