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Updated: Aug 8, 2026
08:30
Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
[Acquired Von Willebrand syndrome]
A Staal-Viliare1, J Didion, Y Rio
1Laboratoire d'hématologie, CHR Metz-Thionville, Groupement des hôpitaux de Metz. a.staal@chr-metz-thionville.rss.fr
Annales De Biologie Clinique
|May 16, 2006
Summary
This case study highlights acquired von Willebrand syndrome (AVWS) in a multiple myeloma patient presenting with bleeding. Early diagnosis and identifying the underlying cause are crucial for effective treatment of this rare bleeding disorder.
Area of Science:
- Hematology
- Oncology
Background:
- Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder.
- It shares laboratory similarities with inherited von Willebrand disease.
- AVWS necessitates differentiation from inherited forms for proper management.
Observation:
- A 54-year-old male presented with sudden mucocutaneous bleeding.
- The patient was diagnosed with multiple myeloma.
- This diagnosis was associated with acquired von Willebrand syndrome.
Findings:
- The case illustrates a link between multiple myeloma and AVWS.
- Laboratory findings in AVWS mimic inherited von Willebrand disease.
- Identifying the underlying etiology is key to managing bleeding.
Implications:
- Accurate diagnosis of AVWS is critical for patient care.
- Understanding the pathophysiology aids in therapeutic strategy.
- Treatment of the underlying condition is essential for resolving AVWS.
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