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Antidiuretic hormone and osmolality in isosorbide therapy and glycerol test
Akinobu Kakigi1, Taizo Takeda, Shoichi Sawada
1Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, Japan. kakigia@med.kochi-u.ac.jp
Abstract:
Changes in plasma antidiuretic hormone (p-ADH) and plasma osmolality (p-Osm) levels were studied in 63 patients with Ménière's disease before and after isosorbide administration and a glycerol test. Increments in both p-ADH and p-Osm levels were observed after isosorbide administration and the glycerol test. The p-ADH secretion appeared to be secondarily stimulated by an increase in the p-Osm level. This p-ADH level increase affects cochlear fluid homeostasis. Based on these results, we must consider both the p-Osm and p-ADH levels when treating patients with Ménière's disease by osmotic diuretics.
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