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Erythropoietin in thyroid cancer.

C M Yates¹, A Patel, K Oakley

¹Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, USA.

Journal of Endocrinological Investigation

|May 16, 2006

Summary

Erythropoietin (Epo) and its receptor (EpoR) are present in thyroid cancer cells. Epo/EpoR signaling alters genes involved in cancer growth, suggesting a role in thyroid cancer progression.

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Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

Erythropoietin (Epo) and its receptor (EpoR) are linked to tumor progression.
Previous studies showed Epo and EpoR expression in papillary thyroid cancer (PTC).
Formalin-fixed tissues limited functional analysis of Epo/EpoR in PTC.

Purpose of the Study:

To investigate the in vitro expression, induction, and function of Epo and EpoR in various thyroid cancer cell lines.
To determine the impact of Epo stimulation on gene expression in thyroid cancer cells.

Main Methods:

Examined Epo and EpoR mRNA expression in papillary (NPA), follicular (WRO), and anaplastic (ARO-81) thyroid cancer cells.
Induced Epo expression using cobalt (hypoxia-mimetic).
Administered Epo to cell lines and analyzed changes in mitogenic gene expression.

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Main Results:

All three thyroid cancer cell lines (NPA, WRO, ARO-81) expressed Epo and EpoR mRNA.
Cobalt treatment induced Epo expression in all cell lines.
Epo administration altered the expression of genes like COX-2, CSN2, WIG1, and CTSD in NPA cells, and CSN2 in ARO-81 cells.

Conclusions:

Thyroid cancers express Epo and EpoR.
Stimulation of the Epo/EpoR pathway induces gene expression changes.
These changes may influence the clinical behavior of thyroid cancers.