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A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

Heiko Witt1, Miklós Sahin-Tóth, Olfert Landt

  • 1Department of Hepatology and Gastroenterology, Charité University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany. heiko.witt@charite.de

Nature Genetics
|May 16, 2006
PubMed
Summary

A specific variant in the PRSS2 gene (G191R) protects against chronic pancreatitis by reducing pancreatic enzyme activity. This finding offers new insights into the genetic factors influencing this inflammatory disease.

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