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[Palpebral cryptococcosis: case report].

Murilo Barreto Souza1, Carlos Sergio Nascimento Melo, Cristiana Silveira Silva

  • 1Departamento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. murilobarreto@ig.com.br

Arquivos Brasileiros De Oftalmologia
|May 16, 2006
PubMed
Summary

A patient with acquired immunodeficiency syndrome developed ocular lesions initially suspected as tuberculosis. Diagnosis revealed Cryptococcus neoformans, successfully treated with amphotericin B, highlighting fungal infections in immunocompromised patients.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Mycology

Background:

  • Acquired immunodeficiency syndrome (AIDS) predisposes individuals to opportunistic infections.
  • Miliary tuberculosis is a disseminated form of tuberculosis that can affect various organs.
  • Ocular involvement in immunocompromised patients requires careful differential diagnosis.

Observation:

  • A patient with AIDS, treated for miliary tuberculosis, developed lesions on the right eyelid and conjunctiva.
  • Initial clinical suspicion pointed towards ocular tuberculosis.
  • Biopsy of conjunctival lesions revealed an encapsulated yeast-like fungus.

Findings:

  • The identified fungus was Cryptococcus neoformans.
  • Treatment with amphotericin B led to the resolution of cutaneous lesions.

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  • This case underscores the importance of considering fungal infections in AIDS patients with ocular manifestations.

    • Implications:

    • Early and accurate diagnosis of fungal infections is crucial in immunocompromised individuals.
    • Ocular findings can be indicative of systemic opportunistic infections.
    • Cryptococcus neoformans should be considered in the differential diagnosis of ocular lesions in AIDS patients.