Consensus guidelines on sedation and analgesia in critically ill children
Related Experiment Video
Updated: Jun 18, 2026

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
Published on: July 30, 2009
Stephen Playfor1, Ian Jenkins, Carolyne Boyles
1Paediatric Intensive Care Unit, Royal Manchester Children's Hospital, Hospital Road, M27 4HA, Manchester, UK. stephen.playfor@cmmc.nhs.uk
Insights
Paediatric Intensive Care Society developed consensus guidelines for sedation and analgesia in critically ill children. These guidelines address the lack of evidence-based practices in paediatric critical care, emphasizing the need for further research.
Area of Science:
- Critical Care Medicine
- Paediatric Intensive Care
- Clinical Practice Guidelines
Background:
- Sedation and analgesia are crucial in pediatric intensive care, yet specific guidelines for critically ill children were lacking.
- Existing adult guidelines are popular, highlighting a gap in pediatric critical care standards.
- A multi-disciplinary panel was formed to address this critical need.
Framework:
- A modified Delphi technique involving three anonymous rounds was employed.
- Consensus was achieved through four dedicated consensus conferences.
- A systematic literature review supported the developed recommendations.
Implementation:
- Twenty key recommendations were established, divided equally between analgesia and sedation.
- Guidelines focus on maintenance sedation and analgesia for critically ill children.
- The evidence base supporting these recommendations was evaluated.
Implications:
- Successfully produced multi-disciplinary consensus guidelines for pediatric sedation and analgesia.
- Highlighted a significant paucity of high-quality evidence in pediatric critical care.
- Emphasized the urgent need for future randomized clinical trials in this field.
Objective:
The United Kingdom Paediatric Intensive Care Society Sedation, Analgesia and Neuromuscular Blockade Working Group is a multi-disciplinary expert panel created to produce consensus guidelines on sedation and analgesia in critically ill children and forward knowledge in these areas. Sedation and analgesia are recognised as important areas of critical care practice and adult clinical practice guidelines in these fields remain amongst the most popular of those produced by the Society of Critical Care Medicine. However, similar clinical practice guidelines have not previously been produced for the critically ill paediatric patient.
Design:
A modified Delphi technique was used to allow the Working Group to anonymously consider draft recommendations in three Delphi rounds with predetermined levels of agreement. This process was supported by a total of four consensus conferences. Once consensus had been reached, a systematic review of the available literature was carried out.
Outcome:
A set of consensus guidelines was produced including 20 key recommendations, 10 relating to the provision of analgesia and 10 relating to the sedation of critically ill children. An evaluation of the existing literature supporting these recommendations is provided.
Conclusions:
Multi-disciplinary consensus guidelines for maintenance sedation and analgesia in critically ill children have been successfully produced and are supported by levels of evidence (excluding sedation and analgesia for procedures and excluding neonates). The working group has highlighted the paucity of high-quality evidence in these important clinical areas and this emphasises the need for further randomised clinical trials in this area.
Related Concept Videos
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Stages of General Anesthesia
Parenteral Anesthetics: Overview
Inhalational Anesthetics: Overview
Drug Dosing: Infants and Children
Pharmacokinetics in Pediatric Patients: Drug Excretion

