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Abnormalities in calcium metabolism in sarcoidosis
P Rottoli1, L Rottoli, S Gommelli
1Institutes of Respiratory Diseases and Internal Medicine, Univ. of Siena, Italy.
Sarcoidosis
|September 1, 1991
Summary
Sarcoidosis patients often exhibit abnormal calcium metabolism (CM), with hypercalciuria being common. This study found hypercalciuria in 34% of sarcoidosis patients, linked to chronic and extrathoracic disease.
Area of Science:
- Nephrology
- Endocrinology
- Rheumatology
Background:
- Sarcoidosis is characterized by extrarenal calcitriol excess, impacting calcium metabolism.
- This can lead to hypercalciuria and, less frequently, hypercalcemia.
Purpose of the Study:
- To investigate calcium metabolism (CM) in a cohort of sarcoidosis patients.
- To determine the prevalence of hypercalciuria and hypercalcemia in this population.
Main Methods:
- Studied calcium metabolism in 44 sarcoidosis patients.
- Assessed the impact of steroid therapy and disease characteristics on CM.
Main Results:
- 34% of patients presented with hypercalciuria, increasing to 39% in untreated individuals.
- Hypercalcemia was detected in only 2.2% of the cohort.
- Hypercalciuric patients more frequently had chronic and extrathoracic (e.g., skin) sarcoidosis involvement.
Conclusions:
- Abnormal calcium metabolism, particularly hypercalciuria, is prevalent in sarcoidosis.
- Hypercalciuria is associated with more severe or chronic forms of sarcoidosis, including extrathoracic manifestations.