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Updated: Aug 8, 2026

Vessel-sparing Excision and Primary Anastomosis
Published on: January 7, 2019
[Vesicoureteric reflux endoscopic treatment complications in childhood]
A Serrano Durba1, M A Bonillo García, F Moragues Estornell
1Servicio de Urología, Hospital La Fe, Valencia.
Insights
Endoscopic treatment for childhood vesicoureteral reflux (VUR) using bulking agents is a safe and effective alternative. Complications are rare, with most cases resolving without significant issues.
Area of Science:
- Pediatric Urology
- Minimally Invasive Surgery
- Medical Device Technology
Background:
- Vesicoureteral reflux (VUR) affects approximately 1% of children, posing a risk for chronic kidney damage.
- Endoscopic injection of bulking agents is an emerging alternative to antibiotic prophylaxis and open surgery for pediatric VUR.
Purpose of the Study:
- To evaluate the complications associated with endoscopic bulking agent injection for treating childhood VUR.
Main Methods:
- Retrospective analysis of 516 endoscopic VUR treatments performed between January 1999 and September 2003.
- Ultrasound was used to assess complications, focusing on ureteral obstruction and agent migration.
Main Results:
- 10 out of 516 patients (1.9%) experienced complications, including ureterohydronefrosis (5 cases, 2 requiring nephrostomy), implant migration (3 cases), epididymitis (1 case), and bladder edema (1 case).
- Macroplastique was used in 8 complicated cases, and Deflux in 2.
Conclusions:
- Endoscopic bulking agent injection is a safe and viable option for managing VUR in children.
- The low complication rate supports its role as an alternative to traditional treatments.
Introduction:
Nowadays, around 1% of children suffer from vesicoureteral reflux (VUR), which represents a risk factor for long-term kidney damage. In the last decade, development in this field has shown that subureteric endoscopic injection of bulking agents for childhood VUR is an acceptable alternative unlike long-term antibiotic prophylaxis and open surgery.
Objective:
To establish the complications of childhood VUR endoscopic treatment.
Material And Methods:
A retrospective analysis was carried out for every patient treated endoscopically in our department from January 1999 to September 2003, with a total amount of 516 implants of submucous bulking agents. All patients were assessed with an ultrasound as a first diagnostic technique so as to establish the complications associated with it, especially ureteral obstruction and injected agent migration.
Results:
Out of 516 cases, Macroplastique was used in 455, Deflux in 44 and Polytef in 17. 10 patients (1.9%) (5 girls/ 5 boys), with ages ranging from 15 months to 11,4 years, presented some kind of complications (Macroplastique was used in 8cases and Deflux in 2). Among them, 5 were remarkable due to an ureterohydronefrosis, 2 of which needed a nephrostomy. 3 patients presented an implant migration, 1 epididymitis and 1 bladder edema.
Conclusions:
Endoscopic bulking agent injection has become a safe alternative to open surgery in childhood VUR management.
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