Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Magnetically and biologically active bead-patterned hydrogels.

Daniel C Pregibon1, Mehmet Toner, Patrick S Doyle

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|May 17, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic monitoring of antibody drug conjugates targeting TROP2 or HER2 in breast cancer using circulating tumor cells.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Inducing radiation resilience in frozen animal cells via mRNA coding for tardigrade damage-suppressor protein in support of space travel and Lunar storage.

The Journal of heredity·2026
Same author

Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells.

Nature·2026
Same author

Reduction in Red Blood Cell Lysis by Polymer Intervention During Rodent Liver Normothermic Machine Perfusion.

Transplantation direct·2026
Same author

Oscillatory flow for contactless particle trapping.

Lab on a chip·2026
Same author

Microfluidic automation improves oocyte recovery from follicular fluid of patients undergoing in vitro fertilization.

Nature medicine·2026
Same journal

Synergistic Visible-Light-Driven CO<sub>2</sub> Reduction and H<sub>2</sub>O Oxidation over Ti<sub>3</sub>C<sub>2</sub> Quantum Dot-Modified Cu/g-C<sub>3</sub>N<sub>4</sub> Photocatalysts.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Spontaneous Phase Separation Enables Rapid, Polymerization-Free Fabrication of Gels.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Lamellar-Confinement-Induced ZIF-67 Nanosheet Mixed Matrix Membranes for Enhanced CH<sub>4</sub>/N<sub>2</sub> Separation.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Structure Control of Oblate Nanoparticles Self-Assembled by ABC Cyclic Terpolymers under Soft Confinement.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Tuning Brønsted/Lewis Acid Site Ratios via Ammonia Modulation for Selective Conversion of Glycerol to 1,3-Propanediol or Solketal.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Catalytic and Nitriding Competition of Nitrogen Atom on Graphene and Its Finite Rate Surface Chemistry Model.

Langmuir : the ACS journal of surfaces and colloids·2026
See all related articles

This study introduces a novel method for precisely arranging microbeads within polymer scaffolds for microfluidic devices. This technique enables efficient cell sorting and analyte detection using patterned microbeads.

Area of Science:

  • Biotechnology
  • Materials Science
  • Microfluidics

Background:

  • Microfluidic devices require precise control over component placement.
  • Nonbiofouling scaffolds are crucial for reliable biological applications.
  • Patterning of microbeads is essential for various microfluidic functions.

Purpose of the Study:

  • To develop a direct patterning method for biologically and magnetically active microbeads.
  • To create nonbiofouling polymer scaffolds for microfluidic applications.
  • To demonstrate the utility of patterned microbeads in cell separation and analyte detection.

Main Methods:

  • Direct patterning of microbeads using UV-initiated photopolymerization.
  • Fabrication of poly(ethylene glycol) (PEG) hydrogel scaffolds covalently linked to glass.

Related Experiment Videos

  • Utilizing microbead opacity for partial or full encapsulation.
  • Integration into microfluidic devices for cell sorting and capture.

    • Main Results:

    • Rapid fabrication of dispersed or packed microbead patterns.
    • Successful separation of B lymphocytes from T lymphocytes using magnetic filtration.
    • Direct capture of B cells on patterned, protein-decorated beads.
    • Demonstrated versatility in creating partially exposed and fully encapsulated bead patterns.

    Conclusions:

    • The developed method offers a versatile and simple approach for microbead patterning in microfluidics.
    • This technology facilitates advanced cell sorting and analyte detection applications.
    • Accurate patterning of diverse microbeads has significant implications for microchip-based detection systems.