[Research on association between atherosclerotic brain infarction and human leukocyte antigen DR gene]
Shuang-yan Zhang1, Ying-quan Wu, Ming Yu
1Harbin The First Hospital, Harbin 150010, Heilongjiang, China.
Objective:
To evaluate the relationship between atherosclerotic brain infarction (ABI) and human leukocyte antigen DR (HLA-DR) gene at molecular level.
Methods:
By using polymerase chain reaction sequence specific probe (PCR-SSP), gene special position of the HLA-II DR alleles were determined in 31 patients and 30 healthy individuals as controls, all of them were inhabitants of Northeastern China.
Results:
The HLA-DR B1*0301 gene frequency in the group of ABI was obviously higher than that of control group (RR=5.6842, P<0.05).
Conclusion:
The HLA-DR B1*0301 gene may be the susceptible gene of ABI in Northeastern China, or it may associate with other genes to produce the disease.
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