Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Targeting dendritic cells in allergen immunotherapy.

Natalija Novak1

  • 1Department of Dermatology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. Natalija.Novak@ukb.uni-bonn.de

Immunology and Allergy Clinics of North America
|May 17, 2006
PubMed
Summary

Allergen immunotherapy induces tolerance by shifting immune responses and activating regulatory T-cells. Further research is needed to understand the precise role of dendritic cells (DCs) in this process.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eczematous component in psoriasis is possibly a negative prognostic factor for deucravacitinib treatment outcome.

Dermatology (Basel, Switzerland)·2026
Same author

Trust in skincare and topical therapies in atopic dermatitis or psoriasis: a German cross-sectional study.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Insights into Api m 10-Isoforms and Splice Variants: More Than One Major IgE-Binding Epitope.

Clinical and translational allergy·2026
Same author

Treatment Preferences Among Systemic Therapy-Naïve Patients with Atopic Dermatitis or Psoriasis in Germany: A Multicentre Study.

Dermatology and therapy·2025
Same author

Anifrolumab has a direct immunoregulatory effect on inflamed keratinocytes: implications for the treatment of lupus erythematosus skin lesions.

Frontiers in immunology·2025
Same author

The respiratory allergy patient's healthcare journey: An international qualitative survey employing an ethnographic approach.

The World Allergy Organization journal·2025

Area of Science:

  • Immunology
  • Allergy Research
  • Immunotherapy

Background:

  • Allergen immunotherapy is a standard treatment for allergic diseases, aiming to induce specific tolerance.
  • Key mechanisms involve shifting T helper 2 (Th2) responses, altering B cell antibody production (IgE to IgG), and enhancing regulatory T-cell function.
  • Dendritic cells (DCs) are crucial for T-cell priming and allergen uptake, but their exact role in immunotherapy-induced tolerance is not fully understood.

Purpose of the Study:

  • To investigate the functional changes of dendritic cells (DCs) during allergen immunotherapy.
  • To elucidate the specific mechanisms by which DCs contribute to allergen-specific tolerance.
  • To validate the hypothesis of DCs as potential targets for immunotherapy.

Main Methods:

Related Experiment Videos

  • Focus on experimental studies examining DC function under immunotherapy conditions.
  • Analysis of DC-mediated T-cell priming and allergen uptake.
  • Evaluation of DC's tolerogenic properties.

    • Main Results:

    • Hypothesized mechanisms of DC involvement in immunotherapy-induced tolerance require further experimental validation.
    • DCs possess bivalent characteristics and tolerogenic properties that could be leveraged in treatment.
    • Understanding DC functional changes is key to closing knowledge gaps.

    Conclusions:

    • Further research into dendritic cell (DC) function is essential for optimizing allergen immunotherapy.
    • DCs may serve as critical targets for enhancing allergen-specific tolerance.
    • Leveraging the tolerogenic potential of DCs could lead to improved therapeutic strategies.