Do telomere dynamics link lifestyle and lifespan?

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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Pat Monaghan1, Mark F Haussmann

  • 1Division of Environmental & Evolutionary Biology, Institute of Biomedical and Life Sciences, Glasgow University, Glasgow G12 8QQ, UK. P.Monaghan@bio.gla.ac.uk

Trends in Ecology & Evolution
|May 17, 2006
PubMed

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
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