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Electrospinning polydioxanone for biomedical applications.

Eugene D Boland1, Branch D Coleman, Catherine P Barnes

  • 1Department of Biomedical Engineering, Virginia Commonwealth University, P.O. Box 980694, Richmond, VA 23298-0694, USA.

Acta Biomaterialia
|May 17, 2006
PubMed
Summary
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Polydioxanone (PDS) nanofibers were fabricated using electrospinning for tissue engineering. Researchers controlled fiber diameter and orientation, influencing mechanical properties for biomedical applications.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Polydioxanone (PDS) is a bioabsorbable polymer initially developed for sutures.
  • PDS exhibits properties like biocompatibility, tunable degradation, and mechanical characteristics, making it suitable for tissue scaffolds.
  • Nanofibrous structures offer unique advantages for biomedical applications due to their high surface area and porosity.

Purpose of the Study:

  • To explore the electrospinning of Polydioxanone (PDS) for creating nanofibrous structures.
  • To investigate the influence of electrospinning parameters on PDS fiber characteristics.
  • To assess the mechanical properties of electrospun PDS scaffolds.

Main Methods:

  • Electrospinning of Polydioxanone (PDS) solutions to produce nanofibrous mats.

Related Experiment Videos

  • Control of fiber diameter by adjusting solution concentrations.
  • Manipulation of fiber orientation using a prototype electrospinning apparatus.
  • Uniaxial mechanical testing to evaluate elastic modulus, peak stress, and strain to failure.

    • Main Results:

    • Successful fabrication of Polydioxanone (PDS) nanofibers via electrospinning.
    • Demonstrated control over PDS fiber diameter based on solution concentration.
    • Achieved control over PDS fiber orientation.
    • Established a correlation between fiber orientation and mechanical properties (elastic modulus, peak stress, strain to failure).

    Conclusions:

    • Electrospinning is a viable method for fabricating Polydioxanone (PDS) nanofibers for biomedical uses.
    • Fiber diameter and orientation can be precisely controlled during PDS electrospinning.
    • The mechanical properties of electrospun PDS scaffolds are significantly influenced by fiber orientation, offering potential for tailored tissue engineering applications.