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Related Experiment Videos

Hippocampal volume in chronic posttraumatic stress disorder (PTSD): MRI study using two different evaluation methods.

A Jatzko1, S Rothenhöfer, A Schmitt

  • 1Central Institute of Mental Health, Faculty for Clinical Medicine Mannheim, University of Heidelberg, Germany.

Journal of Affective Disorders
|May 17, 2006
PubMed
Summary

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This study found no hippocampal volume differences in chronic Posttraumatic Stress Disorder (PTSD) patients compared to controls, even 15 years post-trauma. Findings suggest PTSD may not cause lasting hippocampal changes or they may resolve over time.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • The hippocampus plays a key role in Posttraumatic Stress Disorder (PTSD) pathogenesis.
  • Existing MRI studies on hippocampal volume in PTSD show inconsistent results.
  • Patient trauma heterogeneity and data processing methods may explain inconsistencies.

Purpose of the Study:

  • To investigate hippocampal volume changes in well-characterized chronic PTSD patients.
  • To compare PTSD patients with matched healthy controls.
  • To utilize two distinct evaluation methods for volume assessment.

Main Methods:

  • Recruited 15 chronic PTSD patients from a 1988 air crash and 15 matched controls.
  • Ensured PTSD patients had significant impairment and no substance abuse history.

Related Experiment Videos

  • Analyzed hippocampus volume using semi-automated BRAINS2 and voxel-based morphometry (VBM) with SPM2.

    • Main Results:

    • No significant differences in total brain grey or white matter between groups.
    • No differences in total hippocampal volume, or right/left parts, even after brain volume correction.
    • Voxel-based morphometry (VBM) also revealed no significant hippocampal region differences between PTSD patients and controls.

    Conclusions:

    • This is the first study to compare long-term hippocampal volumes in chronic PTSD using two methods.
    • Neither conventional volumetry nor VBM identified hippocampal volume or structural differences.
    • Results support that hippocampal volume reduction may not be inherent to PTSD or can be restored/develop later.