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Updated: Aug 8, 2026

Visualization of UV-induced Replication Intermediates in E. coli using Two-dimensional Agarose-gel Analysis
10:36

Visualization of UV-induced Replication Intermediates in E. coli using Two-dimensional Agarose-gel Analysis

Published on: December 21, 2010

Involvement of DNA replication in ultraviolet-induced apoptosis of mammalian cells

Luis Francisco Zirnberger Batista1, Vanessa Chiganças, Gabriela Brumatti

  • 1Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, 05508-900 SP, Brazil.

Apoptosis : an International Journal on Programmed Cell Death
|May 17, 2006
PubMed

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DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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