Weight and dimensions of the pituitary in northwestern Indians

Weight and dimensions of the pituitary (hypophysis cerebri) obtained from medicolegal autopsies of northwestern Indian subjects, which included 87 children and adolescents and 798 adults were recorded. Volume of the pituitary was determined in 100 specimens. In addition, anteroposterior and vertical measurement of pituitary were taken in mid-sagittal sections of the head in magnetic resonance images (MRI) of 130 living adults. In the males, the weight of pituitary increased steadily from 102.52 +/- 38.66 mg in the age group of 0-5 years to 427.83 +/- 117.15 mg in the age group of 36-45 years, it decreased thereafter. In the females, the weight increased from 166.10 +/- 38.70 mg in the first age group to 445.90 +/- 168.60 mg in the age group of 16-17 years and became erratic thereafter. The mean weight of the gland in female subjects was always more than in the males of the corresponding ages till 35 years (p < 0.001, p < 0.01, p < 0.05). The maximum weight of the pituitary was observed during adolescence in the females. When weights of the gland of all the age groups were pooled together in adults the average weight was 401.26 +/- 105.89 mg in the males and 417.32 +/- 104.07 mg in the females. The weight and dimensions of the gland in northwestern Indian subjects were smaller than those in the western Caucasians and Japanese. In mid-sagittal MRI pictures of the head, the anteroposterior and vertical measurement of pituitary were about one mm greater than in the autopsy specimens. In the males, weight of the gland was significantly related to body weight in children, adolescents and adults; it was related to supine body length only in the adults. In the females, weight of the gland was significantly correlated with age in all the age group except in the age group of 36-55 years.