Related Experiment Video
Updated: Aug 8, 2026

An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
Published on: January 26, 2019
Genetic diversity of human metapneumovirus over 4 consecutive years in Australia
Ian M Mackay1, Seweryn Bialasiewicz, Kevin C Jacob
1Queensland Paediatric Infectious Disease Laboratory, Royal Children's Hospital, University of Queensland, Queensland, Australia. ian.mackay@uq.edu.au
Abstract:
The molecular epidemiologic profile of human metapneumovirus (hMPV) infection has likely been skewed toward certain genetic subtypes because of assay-design issues, and no comprehensive studies have been conducted to date. Here, reverse-transcription polymerase chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001-2004. After analysis of 727 Australian hMPV strains, 640 were assigned to 1 of 4 previously described subtypes. hMPV was the most common pathogen detected, and subtype B1 was the most common lineage. Concurrent, annual circulation of all 4 hMPV subtypes in our study population was common, with a single, usually different hMPV subtype predominating in each year.
Related Concept Videos
Viral Mutations
Human Virome
Single Nucleotide Polymorphisms-SNPs
Viral Recombination
Respiratory Syncytial Virus Disease
