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Drug-resistant tuberculosis in Castilla-León, Spain, 1996-2000.

A Alberte-Castiñeiras1, M F Brezmes-Valdivieso, A Campos-Bueno

  • 1Departamento de Microbiología, Hospital del Río Hortega, Rondilla de Santa Teresa, 9 E-47010 Valladolid, Spain. aalberte@hurh.sacyl.es

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|May 18, 2006
PubMed
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Drug-resistant tuberculosis (TB) incidence was low in Spain, with no increased resistance observed in HIV-positive patients. Routine surveillance is recommended to optimize TB treatment regimens.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • Tuberculosis (TB) remains a significant global health challenge.
  • Drug resistance in Mycobacterium tuberculosis complicates treatment and control efforts.
  • Understanding resistance patterns in different patient populations is crucial for effective TB control.

Purpose of the Study:

  • To determine the incidence of drug-resistant tuberculosis (TB) in newly treated patients.
  • To compare drug resistance rates between human immunodeficiency virus (HIV)-negative and HIV-positive TB patients.
  • To identify high-risk groups for drug-resistant TB.

Main Methods:

  • A regional anti-tuberculosis drug resistance survey was conducted in Castilla-León, Spain, from 1996-2000.

Related Experiment Videos

  • Mycobacterium tuberculosis strains from 985 newly treated patients (926 HIV-negative, 59 HIV-positive) were analyzed.
  • Univariate and multivariate analyses were employed to assess drug resistance prevalence.

    • Main Results:

    • Overall, 3.8% of isolates showed resistance to streptomycin, isoniazid, rifampicin, or ethambutol.
    • Resistance rates were similar between HIV-negative (3.9%) and HIV-positive (3.4%) patients.
    • Monoresistance was observed in 3.4% of HIV-negative patients; one case of multidrug resistance (isoniazid and rifampicin) was detected.

    Conclusions:

    • The incidence of primary drug resistance in the surveyed area was low.
    • No significant increase in drug resistance was observed in the HIV-positive group compared to HIV-negative individuals.
    • Routine surveillance of drug resistance in representative patient populations is recommended to optimize TB treatment.