Related Experiment Video

Updated: Aug 8, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
08:32

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

Published on: March 16, 2017

Nitric oxide and cell proliferation

Antonio Villalobo1

  • 1Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid, Spain. antonio.villalobo@iib.uam.es

The FEBS Journal
|May 18, 2006
PubMed

Insights

Nitric oxide (NO) regulates cell proliferation by modulating cell cycle arrest. This review details NO's molecular mechanisms, including its effects on cGMP, cell cycle proteins, and signaling pathways.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Nitric oxide (NO) is recognized as a physiological modulator of cell proliferation.
  • NO typically promotes cell cycle arrest, influencing cellular growth regulation.

Purpose of the Study:

  • To explore the molecular mechanisms underlying NO's role in cell proliferation and cell cycle arrest.
  • To discuss the involvement of NO in normal developmental processes.

Main Methods:

  • Review of existing literature on nitric oxide signaling.
  • Analysis of molecular pathways involving cyclic guanosine monophosphate (cGMP).
  • Examination of cell cycle regulators, including cyclins, cyclin-dependent kinases, and retinoblastoma protein.

Main Results:

  • NO modulates intracellular cGMP levels, impacting cell cycle progression.
  • NO influences the expression and activity of key cell cycle regulators like cyclins, CDKs, and retinoblastoma protein.
  • NO's role in tyrosine kinase receptor signaling, such as the epidermal growth factor receptor, is considered.

Conclusions:

  • Nitric oxide plays a critical role in regulating cell proliferation through intricate molecular pathways.
  • Understanding NO's mechanisms provides insights into cell cycle control and normal development.

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