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Updated: Aug 8, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Antifungals and renal safety--getting the balance right
1Department of Liver Disease and Liver Transplantation, Assistance Publique-Hôpitaux de Paris, Hôpital Paul Brousse, Villejuif, France. faouzi.saliba@pbr.aphp.fr
Abstract:
Many patients who receive antifungal agents are immunocompromised or critically ill. This leaves many of these patients prone to renal failure, especially following transplantation. A wealth of clinical data have shown that older antifungal agents, particularly conventional amphotericin B deoxycholate (AmBd), are still highly efficacious, except that AmBd confers extensive nephrotoxicity. This paper examines the pharmacological alternatives that could provide a more suitable balance between clinical efficacy and renal safety.
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