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[Evolution rules and clinical value of apparent diffusion coefficient in cerebral infarction].
Dan Yin1, Li-meng Deng, Xiao-yi Wang
1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China. yindan3418@126.com
Summary
Apparent diffusion coefficient (ADC) values in cerebral infarction evolve over time and space. These changes correlate with infarction stage, aiding treatment decisions and prognosis prediction.
Area of Science:
- Neuroimaging
- Biomedical Engineering
- Radiology
Context:
- Cerebral infarction diagnosis and staging rely on understanding tissue changes.
- Conventional MRI and diffusion-weighted imaging (DWI) are key tools.
- Apparent diffusion coefficient (ADC) and relative ADC (rADC) provide quantitative insights into tissue water diffusion.
Purpose:
- To elucidate the temporal and spatial evolution patterns of ADC values in cerebral infarction.
- To establish correlations between ADC changes and infarction stages (hyperacute, acute, subacute, chronic).
- To provide evidence for improved clinical staging, treatment guidance, and prognosis assessment in cerebral infarction.
Summary:
- Eighty-eight MRI/DWI studies in 69 patients analyzed ADC and rADC in different infarction stages.
- ADC/rADC values were significantly depressed in hyperacute/acute stages, increased in subacute (showing pseudonormalization), and highest in chronic stages.
- Spatial gradients of ADC/rADC varied, with hyperacute/acute lesions showing center-to-periphery increases and subacute lesions showing decreases.
Impact:
- Demonstrates that ADC and rADC exhibit predictable evolution rules in cerebral infarction.
- These rules offer a basis for defining clinical and pathophysiological phases of infarction.
- Findings support using ADC/rADC dynamics for guiding treatment strategies and predicting patient outcomes.