Related Experiment Video

Updated: Aug 8, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

[Pathologic features and prognosis of 21 children with isolated proteinuria]

Xi-qiang Dang1, Zhu-wen Yi, Xiao-jie He

  • 1Laboratory of Pediatric Nephrology, Second Xiangya Hospital, Central South University, Changsha, China. happydang@tom.com

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|May 19, 2006
PubMed

Insights

Children with isolated proteinuria (IP) show varied renal damage, with most recovering after treatment. However, severe mesangial proliferation glomerulonephritis (MsPGN) and focal segmental glomerulosclerosis (FSGS) indicate a less optimistic prognosis for pediatric kidney health.

Area of Science:

  • Pediatric Nephrology
  • Renal Pathology
  • Glomerular Diseases

Context:

  • Isolated proteinuria (IP) in children presents a diagnostic challenge.
  • Renal biopsy is crucial for classifying IP and guiding treatment.
  • Understanding the spectrum of renal damage in pediatric IP is essential for prognosis.

Purpose:

  • To characterize the pathologic features of isolated proteinuria in children.
  • To evaluate treatment outcomes and prognosis in pediatric IP.
  • To identify risk factors for poor outcomes in children with IP.

Summary:

  • Twenty-one children with isolated proteinuria underwent renal biopsy, revealing diagnoses including mesangial proliferation glomerulonephritis (MsPGN), minimal change nephritis (MCN), IgA nephropathy (IgAN), focal segmental glomerulosclerosis (FSGS), and endocapillary proliferative glomerulonephritis (EnPGN).
  • Interstitial changes were noted in MsPGN and FSGS.
  • Most children responded well to medical treatment, achieving recovery without relapse. However, persistent proteinuria and impaired renal function were observed in severe MsPGN and FSGS cases, highlighting the need for vigilant management and renoprotective strategies.

Impact:

  • Provides insights into the diverse histopathological findings in pediatric isolated proteinuria.
  • Demonstrates the effectiveness of aggressive therapies for most children with IP.
  • Underscores the guarded prognosis for severe MsPGN and FSGS, advocating for early intervention to preserve renal function.
Abstract

More Related Videos

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells09:40

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...