Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is thrombolytic therapy effective in elderly patients?

Elena Taneva1

  • 1Medical Faculty, Clinic of Cardiology, Intensive Care, Medical University, Sofia, Bulgaria.

Rejuvenation Research
|May 19, 2006
PubMed
Summary

Thrombolytic therapy (TT) improves outcomes for elderly patients with ST-elevation acute myocardial infarction (AMI). This reperfusion therapy demonstrated positive effects and no complications in patients over 75.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adipokines and treatment with niacin.

Metabolism: clinical and experimental·2006
Same author

Extended-release niacin raises adiponectin and leptin.

Atherosclerosis·2006
See all related articles

Area of Science:

  • Cardiology
  • Geriatrics

Background:

  • Thrombolytic therapy (TT) is standard for acute myocardial infarction (AMI) with ST-segment elevation in younger patients.
  • Elderly patients (>75 years) with AMI and ST-segment elevation often have a poor prognosis without TT.
  • Current guidelines recommend TT for elderly patients undergoing percutaneous transluminal coronary angioplasty (PTCA) or bypass surgery, requiring specialized teams.

Purpose of the Study:

  • To propose recommendations for reperfusion with TT in elderly patients with AMI.
  • To evaluate the efficacy and safety of TT in patients over 75 years old with ST-elevation AMI.

Main Methods:

  • A 5-year observational study (2000-2004) involving 2462 patients with AMI.
  • Focus on 103 patients aged over 75 with ST-elevation AMI.
  • Administration of Reteplase (TT agent) to 10 patients, with assessment of general/mental state, comorbidity, and use of Famotidine for GI bleeding prevention.

Main Results:

  • TT showed a positive effect in patients over 75 with ST-elevation AMI.
  • No complications were observed during TT treatment in this elderly cohort.
  • The oldest treated patient was 93 years old.

Conclusions:

  • Thrombolytic therapy is an effective reperfusion strategy for elderly patients with ST-elevation AMI.
  • TT can improve health outcomes and quality of life in aging populations with AMI.
  • Strategies like dose reduction, controlled blood pressure (≤160/100 mmHg), risk assessment for intracranial hemorrhage, and GI bleeding prevention are crucial for safe TT in the elderly.

Related Experiment Videos