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Targets for deep brain stimulation in Parkinson's disease
Yasin Temel1, Veerle Visser-Vandewalle
1Department of Neurosurgery, University Hospital Maastricht, P. Debyelaan 25, 6202 AZ, Maastricht, The Netherlands. y.temel@np.unimaas.nl
Expert Opinion on Therapeutic Targets
|May 19, 2006
Summary
Deep brain stimulation (DBS) offers treatment for neurological conditions like Parkinson's disease (PD). Patient-specific targeting, considering individual effects, is recommended over disease-specific approaches for optimal outcomes.
Area of Science:
- Neuroscience
- Neurosurgery
- Neurology
Background:
- Deep brain stimulation (DBS) is an emerging technique for treating severe neurological and psychiatric disorders.
- Parkinson's disease (PD) is a primary condition where DBS has been extensively applied, with tens of thousands of patients implanted globally.
Purpose of the Study:
- To review established DBS targets for Parkinson's disease.
- To discuss the merits of patient-specific targeting versus disease-specific targeting in DBS for PD.
Main Methods:
- Review of existing literature on DBS targets used in Parkinson's disease.
- Analysis of stimulation-related positive and negative effects associated with different DBS targets.
Main Results:
- Multiple DBS targets exist for PD, including the thalamus, globus pallidus internus, subthalamic nucleus, pedunculopontine nucleus, and prelemniscal radiation.
- Each target site exhibits unique stimulation-induced benefits and drawbacks.
Conclusions:
- DBS target selection for PD should be individualized based on patient-specific factors.
- Patient-specific targeting offers a more tailored approach to managing Parkinson's disease with DBS.