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Treatment of unilateral compensatory sweating after endoscopical thoracic sympathectomy for general hyperhidrosis

Falk Georges Bechara1, Michael Sand, Georg Moussa

  • 1Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany. f.bechara@derma.de

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|May 19, 2006
PubMed
Abstract

No abstract available in PubMed .

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Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...