Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional compensation in Hedgehog signaling during mouse prostate development.

Jason Doles1, Crist Cook, Xudong Shi

  • 1Department of Surgery, University of Wisconsin-Madison, Box 3236 Clinical Science Center-G5, 600 Highland Avenue, Madison, WI 53792, USA.

Developmental Biology
|May 19, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Collective Asymmetric Synthesis of Eudesmane-Type Sesquiterpenoids from (+)-Verbenone: Production of Atractylenolides, Lactam Analogs, and Dimeric Congeners.

The Journal of organic chemistry路2026
Same author

Social and Anxiety-Like Behaviors Are Affected in Juvenile Mice With Gli2<sup>+/-</sup> but Not Gli3<sup>+/饾洢699</sup> Genetic Modifications.

Brain and behavior路2026
Same author

Preoperative Radiological Features Predict Facial and Cochlear Nerve Function after Vestibular Schwannoma Surgery: A Single-Center Retrospective Study.

World neurosurgery路2026
Same author

Long-term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis.

FEBS open bio路2026
Same author

Symptomatic and pathological features in chemical phlebitis rat model by injection vinorelbine via dorsal pedal vein.

Scientific reports路2026
Same author

Biomechanic characterization of normal urethra using uro-dynamic MRI during voiding.

International urology and nephrology路2026

Hedgehog signaling is crucial for prostate development, but functional redundancy among Gli transcription factors mitigates defects. This study clarifies the complex roles of hedgehog signaling and Gli factors in prostate morphogenesis.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Hedgehog (Hh) signaling is vital for embryonic development, including prostate morphogenesis.
  • Previous studies on Hh signaling's role in prostate development yielded conflicting results due to varied methodologies.

Purpose of the Study:

  • To elucidate the precise role of Hh signaling in prostate ductal budding and glandular morphogenesis.
  • To investigate the functional redundancy among Gli transcription factors in prostate development.

Main Methods:

  • Utilized transgenic mouse models, chemical inhibitors (cyclopamine), and renal grafting.
  • Analyzed Gli1, Gli2, and Gli3 knockout mouse models for prostate development phenotypes.
  • Assessed Hh pathway activity and prostatic differentiation in mutant Urogenital Sinus (UGS) explants.

Related Experiment Videos

Main Results:

  • Genetic loss of Sonic Hedgehog (Shh) led to Indian Hedgehog (Ihh) upregulation and sustained Hh pathway activity.
  • Gli1 and Gli3 are not essential for prostate ductal budding, but Gli2 deficiency caused aberrant budding.
  • Gli2 knockout UGS showed prostatic differentiation with focal hyperplasia; functional redundancy among Gli factors was evident.

Conclusions:

  • Significant functional redundancy exists at both ligand and transcriptional regulatory levels in Hh signaling during prostate development.
  • This redundancy effectively buffers phenotypes resulting from Hh signaling perturbations, explaining previous conflicting data.