Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The experience is CLEAR.

Pranatharthi Chandrasekar1

  • 1Division of Infectious Diseases, Wayne State University School of Medicine, Harper Hospital, Detroit, MI, USA. pchandrasekar@med.wayne.edu

International Journal of Antimicrobial Agents
|May 19, 2006
PubMed
Summary

Amphotericin B lipid complex (ABLC) offers effective antifungal treatment with reduced kidney toxicity compared to conventional amphotericin B. The CLEAR dataset provides extensive safety and efficacy data for ABLC in systemic fungal infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Multicenter Assessment of the Outcomes and Toxicities of Foscarnet for Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex in Immunocompromised Patients.

Open forum infectious diseases·2024
Same author

Impact of Baseline and Week 2 and Week 4 Posttransplant CMV Cell-Mediated Immunity on Risk of CMV Infections and Mortality in Recipients of Allogeneic Hematopoietic Cell Transplant.

Open forum infectious diseases·2023
Same author

<i>Aspergillus</i> Endophthalmitis: Epidemiology, Pathobiology, and Current Treatments.

Journal of fungi (Basel, Switzerland)·2022
Same author

Bloodstream Infections in Hematologic Malignancy Patients With Fever and Neutropenia: Are Empirical Antibiotic Therapies in the United States Still Effective?

Open forum infectious diseases·2022
Same author

SARS-CoV-2 infection: Initial viral load (iVL) predicts severity of illness/outcome, and declining trend of iVL in hospitalized patients corresponds with slowing of the pandemic.

PloS one·2021
Same author

SARS-CoV-2 Viral Load and Myocardial Injury: Independent and Incremental Predictors of Adverse Outcome.

Mayo Clinic proceedings. Innovations, quality & outcomes·2021

Area of Science:

  • Mycology
  • Pharmacology
  • Clinical Medicine

Background:

  • Conventional amphotericin B is a potent antifungal but causes significant nephrotoxicity.
  • Lipid formulations of amphotericin B were developed to mitigate toxicity.
  • Limited robust comparative safety and efficacy data exist for these formulations.

Purpose of the Study:

  • To review clinical data on amphotericin B lipid complex (ABLC).
  • To detail findings from the Collaborative Exchange of Antifungal Research (CLEAR) dataset on ABLC.
  • To assess the safety and efficacy of ABLC in systemic antifungal treatment.

Main Methods:

  • Literature review of clinical data on ABLC.
  • Analysis of the Collaborative Exchange of Antifungal Research (CLEAR) dataset.
  • Evaluation of safety and comparative efficacy of ABLC.

Main Results:

  • ABLC demonstrates comparable efficacy to conventional amphotericin B.
  • ABLC exhibits reduced nephrotoxicity compared to conventional amphotericin B.
  • The CLEAR dataset offers extensive evidence on ABLC's performance.

Conclusions:

  • Lipid formulations, including ABLC, improve the therapeutic index of amphotericin B.
  • ABLC is a viable option for systemic fungal infections, especially when renal function is a concern.
  • Further data analysis supports ABLC's role in antifungal therapy.

Related Experiment Videos