Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Allopurinol improves endothelial function in sleep apnoea: a randomised controlled study.

A A El Solh1, R Saliba, T Bosinski

  • 1Division of Pulmonary, Critical Care, and Sleep Medicine, Dept of Medicine, School of Medicine and Biomedical Sciences and Veterans Affairs Medical Center, University at Buffalo, Buffalo, NY, USA. solh@buffalo.edu

The European Respiratory Journal
|May 19, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Surface-Topography Challenge: A Multi-Laboratory Benchmark Study to Advance the Characterization of Topography.

Tribology letters·2025
Same author

Evolution of carbapenemase-producing Enterobacterales over a 5-year period: worrying increase in acquired cases and patients residing abroad.

The Journal of hospital infection·2024
Same author

An app with brief behavioural support to promote physical activity after a cancer diagnosis (APPROACH): study protocol for a pilot randomised controlled trial.

Pilot and feasibility studies·2022
Same author

Informing patient choice and service planning in surgical voice restoration: valve usage over three years in a UK head and neck cancer unit.

The Journal of laryngology and otology·2021
Same author

Adverse events associated with patient isolation: a systematic literature review and meta-analysis.

The Journal of hospital infection·2021
Same author

Clinicopathological and prognostic significance of programmed cell death ligand 1 expression in patients diagnosed with breast cancer: meta-analysis.

The British journal of surgery·2021

Allopurinol significantly improved endothelial function and reduced oxidative stress in patients with obstructive sleep apnoea. This suggests xanthine oxidase inhibition is a potential therapeutic strategy for this condition.

Area of Science:

  • Cardiovascular Medicine
  • Sleep Medicine
  • Pharmacology

Background:

  • Obstructive sleep apnoea (OSA) is linked to increased oxidative stress, contributing to endothelial dysfunction.
  • Endothelial dysfunction is a key factor in cardiovascular complications associated with OSA.

Purpose of the Study:

  • To investigate if allopurinol, a xanthine oxidase inhibitor, can improve endothelial function in patients with moderate-to-severe OSA.
  • To assess the impact of allopurinol on oxidative stress markers in OSA patients.

Main Methods:

  • A randomized, double-blind, placebo-controlled crossover study involving 12 OSA patients.
  • Treatment involved 300 mg of allopurinol daily for 2 weeks versus placebo.
  • Endothelial function was measured by flow-mediated vasodilation (FMD); oxidative stress was assessed via plasma malondialdehyde (MDA) levels.

Related Experiment Videos

Main Results:

  • Allopurinol significantly increased FMD compared to placebo (10.4% vs. 7.4%).
  • Plasma MDA levels were significantly reduced following allopurinol treatment (1.2 micromol/L vs. 1.5 micromol/L), indicating reduced oxidative stress.
  • Baseline FMD correlated with OSA severity and time spent with oxygen saturation below 90%.

Conclusions:

  • Allopurinol effectively improves endothelial dysfunction in patients with moderate-to-severe obstructive sleep apnoea.
  • Xanthine oxidase plays a significant role in the impaired vasodilation observed in OSA.
  • Inhibition of xanthine oxidase may be a promising therapeutic approach for managing OSA-related endothelial dysfunction.