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BRCA1 promotes induction of ssDNA by ionizing radiation

Brian P Schlegel1, Francine M Jodelka, Rafael Nunez

  • 1Department of Pathology and Section of Hematology/Oncology, University of Illinois Cancer Center, Chicago, Illinois 60607, USA. schlegel@uic.edu

Cancer Research
|May 19, 2006
PubMed

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Homologous Recombination

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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Nucleotide Excision Repair

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