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The acromegalic rosary.

H K Ibbertson1, P J Manning, I M Holdaway

  • 1Department of Medicine, University of Auckland School of Medicine, New Zealand.

Lancet (London, England)
|January 19, 1991
PubMed
Summary
This summary is machine-generated.

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Enlarged costochondral junctions are a common sign in acromegaly patients. This finding can serve as a useful biological marker for growth hormone excess.

Area of Science:

  • Endocrinology
  • Clinical Medicine

Background:

  • Acromegaly, a condition caused by excess growth hormone, presents with various clinical manifestations.
  • Costochondral junctions are anatomical sites susceptible to changes in endocrine disorders.

Observation:

  • Palpable enlargement of costochondral junctions was observed in 26 out of 27 acromegaly patients.
  • A diagnostic study showed a 77% sensitivity and 86% specificity for detecting costochondral enlargement in acromegaly.

Findings:

  • Costochondral enlargement is a prevalent clinical sign in acromegaly.
  • The presence and severity of this enlargement did not correlate with disease duration or hormone levels.
  • This sign was absent in healthy individuals without prior chest injury.

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Implications:

  • Costochondral joint enlargement can be a valuable, non-invasive clinical marker for diagnosing acromegaly.
  • It may indicate past or present growth hormone excess, aiding in patient assessment.