Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Probiotic intervention in neonates--will permanent colonization ensue?

Miguel Gueimonde1, Marko Kalliomäki, Erika Isolauri

  • 1Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland. miguel.gueimonde@utu.fi

Journal of Pediatric Gastroenterology and Nutrition
|May 19, 2006
PubMed
Summary

Lactobacillus rhamnosus GG supplementation in infants showed transient gut colonization. Early presence of this probiotic was linked to a lower risk of developing atopic eczema later in life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary exposure to N-nitrosamines and their precursors: an age-stratified assessment.

Scientific reports·2026
Same author

Intake of live microorganisms and microbial composition in the early stages of life.

Food research international (Ottawa, Ont.)·2025
Same author

Building a roadmap to nutrition for Healthy Ageing: a brief report on the ILSI Europe Healthy Ageing Task Force.

The journal of nutrition, health & aging·2025
Same author

Changes in Healthy Infant Gut Microbiota over the Past Decades.

Neonatology·2025
Same author

Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index.

Molecular nutrition & food research·2025
Same author

Correction: Assessment trial of the effect of enteral insulin on the preterm infant intestinal microbiota.

Pediatric research·2025

Area of Science:

  • Microbiology
  • Pediatric Health
  • Immunology

Background:

  • Probiotics, such as Lactobacillus rhamnosus GG (LGG), are increasingly studied for their potential health benefits in infants.
  • Early life gut microbiota colonization plays a crucial role in immune system development and susceptibility to allergic diseases.
  • Understanding the persistence and impact of specific probiotic strains in the infant gut is essential.

Purpose of the Study:

  • To investigate the transient colonization of Lactobacillus rhamnosus GG in infant feces.
  • To determine the correlation between LGG presence and the later development of atopic eczema.

Main Methods:

  • A randomized, placebo-controlled trial involving 128 infants.
  • Fecal samples were collected at 6 and 12 months of age to monitor LGG presence.

Related Experiment Videos

  • Infants received either LGG or placebo for the first 6 months of life.

    • Main Results:

    • No permanent establishment of Lactobacillus rhamnosus GG was detected in the infant gut.
    • Transient colonization of LGG was observed at 6 months of age.
    • A significant correlation was found between the presence of LGG at 6 months and a reduced prevalence of atopic eczema later in life.

    Conclusions:

    • Lactobacillus rhamnosus GG can transiently colonize the infant gut.
    • Early transient colonization by LGG may have a protective effect against the development of atopic eczema.
    • Further research is warranted to elucidate the mechanisms behind this protective effect.