[Vascular endothelial growth factor in head and neck cancer]

Angiogenesis plays a major role in tumor progression and metastasis. The family of vascular endothelial growth factors (VEGF) and their receptors with tyrosine kinase activity are main mediators of angiogenesis. Some researchers interested in angiogenesis assessed a value of determination of VEGF and his receptors in tissues and serum of patients with head and neck cancer. The correlation between clinical and pathological parameters and the level of the proangiogenic factor, their prognostic value and the influence on tumor radioresistance was evaluated.