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Published on: February 15, 2022

Ocular changes with oxaliplatin

Denise O'Dea1, Catherine M Handy, Ann Wexler

  • 1St. Vincent's Comprehensive Cancer Center, New York, NY, USA. dodea@aptiumoncology.com

Clinical Journal of Oncology Nursing
|May 20, 2006
PubMed

Insights

Oxaliplatin chemotherapy can cause rare but reversible vision problems, including tunnel vision and visual loss. Clinicians should monitor patients for these unusual ocular toxicities.

Area of Science:

  • Oncology
  • Ophthalmology
  • Neuro-oncology

Background:

  • Chemotherapeutic agents, including platinum compounds, can cause ocular toxicity.
  • Oxaliplatin is a widely used platinum compound in cancer treatment.

Observation:

  • This report details four patients experiencing ocular symptoms during oxaliplatin therapy.
  • Symptoms included tunnel vision and visual loss, particularly with postural changes.

Findings:

  • One patient presented with papilledema, an objective sign of increased intracranial pressure.
  • All reported ocular side effects were reversible upon discontinuation or management of oxaliplatin treatment.

Implications:

  • Clinicians must remain vigilant for rare ocular toxicities associated with oxaliplatin.
  • Early recognition and management of these visual disturbances are crucial for patient care.

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