[Correlation between dynamic contrast-enhanced MRI and expression of microvascular density in the glioma]
Dan Yin1, Xiao-yi Wang, Xue-bin Yan
1Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China). yindan3418@126.com
Objective:
To explore the correlation between microvascular density (MVD) and dynamic contrast-enhanced MRI in the glioma.
Methods:
We examined 35 patients with histologically verified glioma. Gadolinium-enhanced dynamic TurboFLASH imaging was performed preoperatively in all patients followed by conventional MRI. The steepest slope (SSmax) of curve and corresponding Tm1 in "first-pass" phase were obtained by analyzing time-signal curve. All specimens were immunostained with anti-human Factor VIII relative antigen monoclonal antibody postoperatively by streptavidin-peroxidase method to obtain the MVD. The correlation between SSmax, Tm1, and MVD was analyzed.
Results:
SSmax was positively correlated with MVD (r = 0.640, P < 0.01). Tml was negatively correlated with MVD (r = -0.671, P < 0.01).
Conclusion:
The MVD correlates obviously with SSmax and Tml in the glioma. Analyzing the time-signal curve of dynamic contrast-enhanced MRI is helpful to predict the angiogenesis in the glioma.
More Related Videos
04:30A Photopolymerizable Hyaluronic Acid-Collagen Model of the Invasive Glioma Microenvironment with Interstitial Flow
Published on: October 18, 2024
09:17Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
Published on: September 13, 2022